The Major League Soccer season began on March 2, 2013, following preseason events in Tucson, Arizona, Orlando, Florida, and Charleston, South Carolina.

On January 23, 2013, USL Pro announced an alliance with Major League Soccer.

Those matches will count toward USL Pro standings, giving each team a total of 26 games.

Except for Antigua Barracuda FC (who will play two MLS reserve teams on the road), each set will be a home-and-away arrangement.

The 100th edition of the annual national championship, the 2013 Lamar Hunt U.S. Open Cup, ran from May 7 through October 2.

D.C. United defeated Real Salt Lake 1–0 in the final to qualify for the 2014–15 CONCACAF Champions League Group stage.