This was also John Fox's final year as the Broncos' head coach after four seasons, as he mutually agreed to part ways with the team on January 12, 2015, due to poor playoff performances during his tenure, including no playoff wins in 2012 and 2014, as well as suffering a blowout loss in Super Bowl XLVIII, as general manager John Elway felt the Broncos hadn't shown enough fight at critical times in the postseason.

[5] On July 23, one day before the start of the Broncos' training camp, owner Pat Bowlen relinquished control of the team due to his battle with Alzheimer's disease.

[68] On September 2, wide receiver Wes Welker was initially suspended for the first four games of the season for testing positive for the amphetamine Adderall, a violation of the league's substance-abuse policy.

On the Colts' first offensive possession of the second half, the Broncos' defense made a goal-line stand, as linebacker Brandon Marshall snuffed out Luck's attempt of a quarterback sneak on 4th-and-goal.

The Colts attempted a rally, however, Broncos' cornerback Bradley Roby broke up a 4th-down pass from Luck that was intended for wide receiver Reggie Wayne on the first play after the two-minute warning.

On the second play after the two-minute warning, Broncos' defensive end DeMarcus Ware forced a fumble off Smith; however, it was ruled an incomplete pass following a replay review.

On the next play, Smith connected on a 21-yard pass to wide receiver Dwayne Bowe, and was pushed out of bounds at the Broncos' 9-yard line by cornerback Chris Harris, Jr. with 1:51 remaining in the game.

Three plays later, Lynch was tackled in the end zone by linebacker Nate Irving and cornerback Aqib Talib for a Broncos' safety to narrow the Seahawks' lead to 17–5.

However, the Seahawks won the overtime coin toss, and methodically marched down the field with a 13-play, 80-yard drive, culminating in a game-winning 6-yard touchdown run by Lynch to end the game.

Cardinals' quarterback Drew Stanton, playing in place of an injured Carson Palmer, was knocked out of the game with a concussion by Broncos' linebacker Von Miller.

Coming off their win over the Cardinals, the Broncos returned to the site of Super Bowl XLVIII and flew to East Rutherford, New Jersey, for an AFC match against the New York Jets at MetLife Stadium.

The Jets had one last possession deep in their own territory, however, on the third play, Smith was intercepted by Broncos' cornerback Aqib Talib, who ran 22 yards into the end zone for the game-clinching touchdown.

Coming off their dominant win over the 49ers, the Broncos remained on home ground for an AFC West duel against the San Diego Chargers on Thursday Night Football.

After the two teams traded punts on their next possessions, the Chargers tied the game with a time-consuming drive, culminating with 2-yard touchdown pass from quarterback Philip Rivers to wide receiver Keenan Allen.

The drive was kept alive by a defensive holding penalty on Chargers' safety Marcus Gilchrist that negated an Eric Weddle interception of Manning near the goal line.

On the Patriots' first possession of the second half, Brady was intercepted by Broncos' cornerback Bradley Roby, and six plays later, Manning connected on an 18-yard touchdown pass to tight end Julius Thomas to narrow the gap to 27–14.

Quarterback Peyton Manning shook off two early interceptions and connected on a pair of touchdown passes within the last three minutes of the first half – 51-yarder to running back C. J. Anderson and a 32-yarder to wide receiver Emmanuel Sanders.

On the tenth play of the drive, the Broncos opted to go for a first-down on a 4th-and-5 from the Rams' 37-yard line rather than attempt a long field goal, however, a pass from quarterback Peyton Manning to wide receiver Emmanuel Sanders fell incomplete.

[76] On the fourth play of the Broncos' first possession of the second half, Sanders suffered a concussion after absorbing a helmet-to-helmet hit from Rams' safety Rodney McLeod, and did not return.

The Dolphins attempted a rally, with Tannehill connecting on a 1-yard touchdown pass to Landry, coupled with running back Lamar Miller rushing for a two-point conversion, with 1:37 remaining in the game.

The Broncos jumped out to a 14–0 lead on their first two possessions in the first quarter, with quarterback Peyton Manning throwing a pair of touchdown passes – a 23-yarder to wide receiver Demaryius Thomas and a 15-yarder to running back C. J. Anderson.

The scoring play occurred after the Broncos' special teams fooled the Chiefs with a fake punt run by safety David Bruton and a fourth-down conversion by Anderson.

The Broncos subsequently marched all the way to the Chargers' 1-yard line, but were once again forced to settle for another 19-yard field goal by Barth, after a 1-yard touchdown run by C. J. Anderson was overturned by an instant replay review just after the two-minute warning.

Broncos' quarterback Peyton Manning, battling through flu-like symptoms, suffered a thigh injury while attempting to throw a block on the overturned touchdown run.

The two teams traded punts on their next possessions, and the Broncos attempted a rally, however, Bengals' cornerback Dre Kirkpatrick returned an interception off Manning 30 yards for a touchdown.

The Raiders got on the scoreboard, when defensive end Justin Tuck deflected a lateral by quarterback Peyton Manning that was intended for wide receiver Emmanuel Sanders, and cornerback Keith McGill recovered and ran 18 yards for a touchdown.

Later in the fourth quarter, linebacker Lerentee McCray forced a fumble off Carr, and cornerback Tony Carter recovered and ran 20 yards for a touchdown.

[118] The Broncos' offense went three-and-out on the opening possession of the second half, and the Colts subsequently added to their lead, with an 11-play, 72-yard drive that chewed up over eight minutes, culminating in a 15-yard touchdown pass from Luck to wide receiver Hakeem Nicks.

Both teams went three-and-out on their next possessions, and the Colts added to their lead, with another time-consuming drive that chewed up eight minutes off the clock, culminating in a 30-yard field goal by placekicker Adam Vinatieri with 4:11 remaining in the game.

[122] Manning withdrew from the Pro Bowl due to the quad injury that he suffered during a Week 15 game vs. the San Diego Chargers and played through during the playoff loss to the Indianapolis Colts.