In the postseason, the Colts would defeat both the Cincinnati Bengals and Denver Broncos before losing to the eventual Super Bowl Champion New England Patriots in the AFC Championship Game.

The 2014 Colts failed to join the 2010 New York Jets and 2012 Baltimore Ravens as the only teams to beat both Tom Brady and Peyton Manning in the playoffs.

Behind former first overall draft pick Andrew Luck, the Colts became the first team since the AFL–NFL merger in 1970 to pass for 300 or more yards in eight consecutive games.

As of 2024, this is the deepest postseason run the Colts have ever had in the post-Peyton Manning era, and the only season since 2009 where they have made the AFC Championship Game.

Draft trades On May 16, it was announced the outside linebacker Robert Mathis was suspended for the first four games of the season for violating the league's substance-abuse policy.

[30] On September 29, it was announced the safety LaRon Landry was suspended for four games of the season for violating the league's substance-abuse policy.

Peyton Manning led the Broncos' offense on a 16-play drive, but would settle only for a field goal, giving Denver a 3–0 lead.

Late in the second quarter, the Broncos again scored on a touchdown pass from Manning to Thomas and extended Denver's lead to 24–0 with two minutes remaining in the half.

A 48-yard drive early in the fourth quarter gave the Broncos as 31–10 lead after a Montee Ball touchdown run.

The Colts would respond on their next drive with a touchdown pass from Luck to Dwayne Allen, cutting the Broncos' lead down to two scores.

The Colts failed to take advantage of a recovered onside kick, after Luck threw an interception in Broncos' territory.

After back-to-back losses to begin the season, the Colts faced their AFC South rival, the Jacksonville Jaguars.

After a fumble recovery by Darius Butler late in the first half, they were set up with good field position in Jaguars territory.

[38] After struggling to move the ball in the first half, the Jaguars replaced quarterback Chad Henne with rookie Blake Bortles.

The Colts scored their first points of the second half on a pass from Luck to Hakeem Nicks early in the fourth quarter.

Late in the fourth quarter the Colts defense extended the lead, with an interception returned for a touchdown by Greg Toler.

An onside kick gave the ball back to the Colts, which led to an eleven play, 44-yard drive that ended in a touchdown pass from Luck to Dwayne Allen.

The Colts' defense again forced a turnover on the Titans' next possession, with Charlie Whitehurst throwing an interception to Mike Adams.

On the first play of the Ravens' offensive possession, Steve Smith fumbled the ball, which was then recovered by Montori Hughes of the Colts.

After a stalled Ravens' drive early in the second quarter, the Colts drove 70 yards in 20 plays, though they again settled for a Vinatieri.

The Ravens responded, scoring on a 52-yard field goal from Justin Tucker as time expired, cutting the Colts' lead to 6–3 at halftime.

[42] The Ravens opened the second half on offense and committed their third turnover on a Joe Flacco interception by Vontae Davis.

Following three straight wins, the Colts traveled to NRG Stadium for a divisional matchup against the Houston Texans on Thursday Night Football.

On the Colts' next offensive drive, they scored on a touchdown pass from Andrew Luck to Ahmad Bradshaw, extending their lead to 17–0.

Midway through the fourth quarter, Texans' defensive end J. J. Watt forced a fumble that was returned for 45-yards for a touchdown and again closing the Colts' lead to one possession.

[43] Punter Pat McAfee was recognized for his league best 44.8 yard punt average, as well as his third successful onside kick of the season, by being named the AFC Special Teams Player of the Week.

With the win, the Colts clinched the AFC South title for a second consecutive season while improving to 10–4 and 13–0 against the Texans at home.