RVA Football Club were the defending champions, having won their first NPSL title the previous season.
The conference included 7 teams spread across 6 different states for the 2014 season with the addition of expansion club Greater Lowell United FC.
Kabba Joof, Head Coach of Rhode Island Reds FC served as the Conference commissioner.
The maximum travel distance for the season was between Seacoast United Mariners and the New York City area clubs at just over 300 miles.
Due to unforeseen circumstances, Puerto Rico FC did not participate in the 2014 NPSL season.
[43] In a new format for 2014, the top four teams of the Southeast Conference played for a spot in the South Region playoffs.
[20] The Midwest Region Champion was decided by a weekend tournament among the winner of each of the three conferences, as well as one wild card team.
The wild card was awarded to the remaining team from among all the conferences with the highest regular season points-per-game.
The region held its annual general meeting in San Diego, California, on January 12.
[43] In a new format for 2014, the top four teams of the Southeast Conference played for a spot in the South Region playoffs.