Marin Čilić defeated Kei Nishikori in the final, 6–3, 6–3, 6–3 to win the men's singles tennis title at the 2014 US Open.

Čilić was the second Croatian to win a men's singles major, after his coach Goran Ivanišević at the 2001 Wimbledon Championships.

[3] Nishikori became the first Japanese in the Open Era to reach a major semifinal and final, and the first since Jiro Sato at the 1933 French Championships.

The finalists defeated Roger Federer and Novak Djokovic in their respective semifinals, guaranteeing a new major champion.

This marked the first US Open appearance of future champion Dominic Thiem; he lost in the fourth round to Tomáš Berdych.