Incumbent Republican Senator Pat Roberts was re-elected to a fourth term against Independent Greg Orman and Libertarian nominee Randall Batson.

[3] Primary opponent Milton R. Wolf, a radiologist, was under investigation by a state medical ethics board for posting X-ray images of dead patients with macabre commentary to Facebook.

Roberts also began spending more time in Kansas, living out of a hotel in Topeka rather than from his home in Alexandria, Virginia.

[57] The state district court in Shawnee County threw out the petition, meaning no replacement for Taylor needed to be named.

Roberts defeated Orman in the general election, winning reelection to a fourth term in office.