The 2014 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts.

It was the 46th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and was part of the ATP World Tour 250 Series of the 2014 ATP World Tour.

It took place at the Wake Forest University in Winston-Salem, North Carolina, United States, from August 17 through August 23, 2014.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair used a protected ranking to gain entry into the doubles main draw: The following pair received entry as alternates: Lukáš Rosol def.

Jerzy Janowicz, 3–6, 7–6(7–3), 7–5 Juan Sebastián Cabal / Robert Farah def.