[8] On 1 July, Atlético announced the departure of centre back Miranda to Italian Serie A club Internazionale.

On 20 July, Atlético reached an agreement with Fiorentina for the transfer of Montenegrin international centre back Stefan Savić.

[17] Atlético also confirmed the signing of Bernard Mensah from Portuguese side Vitória de Guimarães; he was immediately loaned to Getafe for the entirety of the 2015–16 season.

[18] On 25 July, Atlético played its first friendly game of the pre-season, prevailing 2–0 over Numancia in the Jésus Gil Trophy; Lucas Hernandez and Ángel Correa both scored.

On 28 July, Atlético confirmed the return of left back Filipe Luís after one year spent in the English Premier League with Chelsea.

[19] On the same day, Atlético played its second friendly game of the pre-season and won 2–0 against Real Oviedo, with goals Antoine Griezmann and Fernando Torres.

On 29 July, Atlético, with 22 players, prepared to play two friendlies in Japan and China for the LFP World Challenge tour.

[20] 1 August marked the first match of the tour, in Japan, where Atlético defeated Sagan Tosu 4–1 in penalties, the club's third win of the pre-season.

[21] Its second, and last match, in Asia was played on 4 August in China, with Atlético defeating Shanghai SIPG 0–3 through an Antoine Griezmann goal and a double from Fernando Torres.

In the day's third match, played in the evening, Atlético defeated Real Sociedad 2–0 through a goal by Markel Bergara and a strike by Griezmann.

[23] On 13 August, Atlético confirmed that Mexican striker Raúl Jiménez officially signed with Portuguese club Benfica.

[24] On 14 and 15 August, Atlético played its last two friendly matches of the pre-season, contending in the Ramón de Carranza Trophy.

Atlético then dispatched Real Betis with three goals from José Giménez, Jackson Martínez and Ángel Correa, thereby claiming the side's tenth Carranza Trophy.

[28] Atlético won its second-straight Liga match after defeating Sevilla at the Sánchez Pizjuán 3–0, with goals from Koke, Gabi and Jackson Martínez.

[31] On 15 September, Atlético played its first match in the Champions League group stage, winning 2–0 over Galatasaray, with two goals from Antoine Griezmann.

[32] With goals in the second-half from Ángel Correa and Fernando Torres, Atlético has achieved an important victory by closing a week against Eibar.

[42] Back in La Liga, on 8 November Atético defeated Sporting de Gijón 1–0 from an Antoine Griezmann goal in the 93rd minute.

[44] A double from Griezmann—as in the first leg was enough to down Turkish side Galatasaray, 2–0, in the Champions League group stage at home, ensuring Atlético's progression to the round of 16.

Griezmann, with a great goal, decided the match in the 76th minute to put the club at the top of the table after the 2–1 home win.

[51] After the first-leg win away at Reus in the Copa del Rey, Thomas scored the second leg's only goal for Atlético (1–0) to send the club through to the round of 16, 3–1 on aggregate.

[53] On 30 December, Atlético responded with an important 0–2 away win over Rayo Vallecano to finish the 2015 calendar year with goals from Ángel Correa and Antoine Griezmann.

[59] In the second leg of the Copa del Rey's round of 16, played on 14 January, Atlético overwhelmed Rayo Vallecano 3–0 at the Vicente Calderón, securing a 4–1 aggregate victory and progression to the quarter-finals.

[60] Three days later, on 17 January, a great goal from Filipe Luís and double from Griezmann was enough to dispatch Las Palmas 0–3 away at the Gran Canaria.

[61] On 20 January, Atlético played-out a hard-fought 0–0 draw away at Celta in the first leg of the Copa del Rey quarter-finals.

[63] Despite goals from Antoine Griezmann and Ángel Correa, Atlético fell to Celta 2–3 in the away leg of the Copa del Rey quarter-finals, knocking the club out of the cup 2–3 on aggregate.