Team practices began in October 2015, followed by the start of the regular season on November 13.
Conference play began on January 2, 2016, and concluded on March 5.
Kansas won their 12th straight Big 12 regular season championship by finishing 33–5 overall and 15–3 in conference play, two games ahead of second-place West Virginia.
The 2016 Big 12 men's basketball tournament took place from March 9–12, 2016 at the Sprint Center in Kansas City.
Kansas won the tournament for the 10th time in school history.