The Bulls, led by fourth year head coach Felisha Legette-Jack, played their home games at Alumni Arena as members of the East Division of the Mid-American Conference.

Buffalo finished the regular-season tied for seventh in the conference and were assigned the eight seed for the 2016 MAC women's basketball tournament.

After upsetting the fifth seed Akron 88–87 in the semifinals, they face the second-seeded Central Michigan for the tournament championship.

The ball was inbounded to Stephanie Reid who dribbled around a screen and put up a shot that went off the glass, and through the net to win the game 73–71.

The win gave Buffalo the first ever championship of the Mid-America Conference and their first ever invitation to the NCAA tournament.