América were the defending champions, and won their second consecutive title, and seventh CONCACAF club title (including the CONCACAF Champions' Cup era), by beating fellow Mexican team Tigres UANL 4–1 on aggregate in the final.

Nine teams from the North American Football Union (NAFU) qualify to the Champions League.

If a team reaches both tournament finals, the vacated berth is reallocated through regular season record.

For the United States, three berths are allocated through the Major League Soccer (MLS) regular season and playoffs; the fourth berth is allocated to the winner of its domestic cup competition, the Lamar Hunt U.S. Open Cup.

Because Canada hosted the 2015 FIFA Women's World Cup, the 2015 Canadian Championship, typically played April–May, was extended, with the finals in August.

[5] Twelve teams from the Central American Football Union (UNCAF) qualify to the Champions League.

The draw for the tournament was held on June 1, 2015, 20:00 EDT (UTC−4), at the New World Center in Miami Beach, Florida.

Each tie was played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg.

[3] Starting from this season, the higher-seeded team in each tie would host the second leg throughout the knockout stage.