The Clarkson Golden Knights women's ice hockey program represented Clarkson University during the 2015–16 NCAA Division I women's ice hockey season.
In the ECAC tournament they advanced to the championship game before falling to regular season champion Quinnipiac.
Their performance was still enough to earn a fourth-straight at-large the NCAA tournament bid.
In the quarterfinals, they upset Quinnipiac, sending them to their second ever Frozen Four.
In the semifinals, they fell in overtime to an undefeated and untied Boston College team.