The 2015–16 Copa del Rey de Balonmano was the 41st edition of this tournament, organized by Liga ASOBAL.

FC Barcelona Lassa won its 17th Copa del Rey title after defeating host team Helvetia Anaitasuna in the Final 33–30.

The draw took place on 29 October 2015 at RFEBM's headquarters.

The Final Four was played on 7/8 May at Pabellón Anaitasuna in Pamplona, Navarre.

[4] Helvetia Anaitasuna's win over Naturhouse La Rioja in semifinals qualified it for 2016–17 EHF Cup as FC Barcelona, Naturhouse La Rioja and ABANCA Ademar León are already qualified for European competitions via Liga ASOBAL.