The Final was held in Seville at Pabellón de San Pablo on 1 May 2016.
Movistar Inter was the defending champion but lost in Quarter-finals to Palma Futsal.
Eventually, ElPozo Murcia won its first ever Copa del Rey title after defeating Palma Futsal 3–2 in the Final.
Round of 16 draw was held on Friday 2 October at RFEF headquarters.
The final will be played on 7 May at the Pabellón San Pablo located in Seville.