The 2015–16 Creighton Bluejays men's basketball team represented Creighton University in the 2015–16 NCAA Division I men's basketball season.

The Bluejays, led by sixth-year head coach Greg McDermott, played their home games at the CenturyLink Center Omaha, and were members of the Big East Conference.

They lost to Seton Hall in the quarterfinals of the Big East tournament.

They defeated DePaul in the first round of the Big East tournament and lost to Georgetown in the quarterfinals.

The Bluejays finished with a losing record for the first time in 18 years, dating back to the 1995–96 season.