The 2015–16 Czech First League, known as the Synot liga for sponsorship reasons, was the 23rd season of the Czech Republic's top-tier football league.
Defending champions Viktoria Plzeň won the league for a second consecutive season, winning their fourth Czech title as a result.
Sigma Olomouc, the 2014–15 FNL champion, returned to the First League just one season after their relegation.
Runner-up FK Varnsdorf were not promoted as their stadium failed to meet the league requirements.
Instead, FC Fastav Zlín rejoined the top level for the first time since the 2008–09 season.