The 2015–16 Damehåndboldligaen (known as the Primo Tours Ligaen for sponsorship reasons) was the 80th season of the Damehåndboldligaen, Denmark's premier Handball league.

The reigning champions were FC Midtjylland.

Team Esbjerg won the title, when they beat FC Midtjylland in the final.

SønderjyskE Håndbold were relegated, as they finished last in the regular season.

Skive fH was originally going to play in the league in the 2015-16 season but the club's economy forced them to withdraw and their place was offered to Nykøbing Falster Håndboldklub instead.