The 2015–16 DePaul Blue Demons men's basketball team represented DePaul University during the 2015–16 NCAA Division I men's basketball season.

They played their home games at the Allstate Arena, and were members of the Big East Conference.

Dave Leitao returned to Chicago to lead the Blue Demons for the second time, following a three-year tenure from 2002–2005.

The Blue Demons finished the 2014–15 season with record of 12–20 (6–12 Big East), tied for 7th in the conference.

Following the season, head coach Oliver Purnell resigned[2] and was replaced by Leitao.