The 2015–16 División de Honor was the 49th season of the top flight of the Spanish domestic rugby union competition since its inception in 1953.

El Salvador won its eighth División de Honor title after defeating local arch-rivals Valladolid in the Final 24–23, held at Estadio Pepe Rojo on 28 May.

The season took place between September and March, with every team playing each other home and away for a total of 22 matches.

The relegation playoff was played over two legs by Bizkaia Gernika, the team finishing 11th in División de Honor, and CAU Valencia, the losing team from División de Honor B promotion playoff final.

Bizkaia Gernika won 129–25 on aggregate and remained in División de Honor for 2016–17 season.