The 2015–16 Duquesne Dukes men's basketball team represented Duquesne University during the 2015–16 NCAA Division I men's basketball season.

The Dukes, led by fourth year head coach Jim Ferry, played their home games at the A. J. Palumbo Center and were members of the Atlantic 10 Conference.

They lost to La Salle in the first round of the A-10 tournament.

The Dukes were invited to the College Basketball Invitational where they defeated Nebraska–Omaha in the first round before losing in the quarterfinals to Morehead State.

They advanced to the second round of the A-10 tournament where they lost to George Washington.