The 2015–16 EHF Challenge Cup is the ongoing 19th edition of the European Handball Federation's third-tier competition for men's handball clubs, running from 11 October 2015 to 22 May 2015.

All draws held at the European Handball Federation headquarters in Vienna, Austria.

Some teams agreed to play both matches in the same venue.

Some teams agreed to play both matches in the same venue.

Some teams agreed to play both matches in the same venue.