The 2015–16 season was Empoli Football Club's second consecutive season in Serie A after their promotion from Serie B at the end of the 2013–14 season.

Having finished 15th the previous season, Empoli is competing only in domestic competition, in both Serie A and the Coppa Italia.

Empoli's pre-season began with the departure of manager Maurizio Sarri to Napoli.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.