The 2015-16 Ethiopian Premier League is the 69th season of top-tier football in Ethiopia.
Saint George SC were the defending champions, having won their 24th championship.
The two newcomers were Dire Dawa City and Hadiya Hossana FC.
The teams finishing in the bottom two places were relegated to the National League for 2015-16.
Saint George SC are the defending champions from the 2014–15 season.