Teams and seedings were unveiled by FIBA Europe on 3 July 2015.

[1] 17 teams registered for EuroLeague Women 2015–16,[2] resulting in 15 direct qualifiers, and one preliminary round to be played between BK Brno and CB Avenida.

[3] However, on August 6, BK Brno announced its withdrawal from European competitions due to financial reasons, automatically qualifying Perfumerías Avenida to the Regular Season[4] Regular season will start on October 14 and will finish on February 10, 2016.

The four top teams of each group will qualify to the quarterfinals.

If teams are level on record at the end of the Regular Season, tiebreakers are applied in the following order: Quarter-finals will be played on March 8, 11 and 16, 2016.