The 2015–16 season is FC Sheriff Tiraspol's 19th season, and their 18th in the Divizia Naţională, the top-flight of Moldovan football.

Sheriff Tiraspol are the current defending champions of the Moldovan Cup, and were knocked out of the Europa League by Norwegian side Odds BK, whilst defeating FC Milsami Orhei in the Moldovan Super Cup.

Prior to the start of the season, 27 May 2015, Lilian Popescu was appointed as Sheriff Tiraspol's new manager.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.