The 2015–16 Spartak Moscow season was the 24th successive season that the club played in the Russian Premier League, the highest tier of association football in Russia.

Spartak Moscow took part in the Russian Cup and also took part in 2016–17 UEFA Europa League season.

Following the termination of Murat Yakin's contract as manager on 30 May 2015,[1] with Dmitri Alenichev being appointed as manager on 10 June 2015.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.