The 2015–16 season was Frosinone Calcio's first-ever season in Serie A.

The team was promoted to the first division after finishing second in the 2014–15 Serie B, and competed in Serie A and the Coppa Italia.

They were relegated back down to Serie B after just one season in the top flight.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.