The 2015–16 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross during the 2015–16 NCAA Division I men's basketball season.

The Crusaders, led by first year head coach Bill Carmody, played their home games at the Hart Center and were members of the Patriot League.

As the #9 seed, they defeated Loyola (MD), Bucknell, Army, and Lehigh to be champions of the Patriot League tournament and earn the conference's automatic bid to the NCAA tournament.

As a #16 seed in the First Four they defeated Southern to advance to the first round where they lost to Oregon.

They advanced to the quarterfinals of the Patriot League tournament where they lost to Bucknell.