2015–16 Honduran Liga Nacional

A total of 10 teams will contest the tournament, including 9 sides from the 2014–15 season plus Juticalpa F.C., promoted from the 2014–15 Liga de Ascenso.

[13] That Olimpia's defeat represented their first time losing three consecutive games playing in Tegucigalpa since 2001 and their worst season start ever with a 1–0–4 record at the moment.

[15] That same night, Olimpia's coach Héctor Vargas reached his 400 game as a manager in the Honduran Liga Nacional since his debut in 1998.

Real Sociedad as he was hired by the El Salvador national football team on their quest to the 2018 FIFA World Cup.

[17] On 4 October, Malian defender Mamadou Traoré became the first African player to score a goal in the history of the league in the Platense's 2–1 win over Vida.

On 10 December, international midfielder and Olimpia player Arnold Peralta was shot dead by a gunman in La Ceiba, five days after playing his last game in the semifinals.

[23] This Honduras Progreso's win marks their fourth consecutive victory playing in their season's inaugural game, a flawless record since their promotion in 2014.

[24] For their second year in a row, Club Deportivo Olimpia launched an exclusive yellow jersey which will be used in the month of February to show their support to the fight against Childhood cancer.

Meanwhile, Leonardo Isaula played its 502nd match in the history of the league, breaking the previous mark left by Rony Morales who had 501 appearances.