The team played its home games in Lexington, Kentucky for the 40th consecutive season at Rupp Arena, with a capacity of 23,500.

Isaiah Briscoe, originally from Newark, New Jersey, was the third highest rated point guard that Calipari had signed at Kentucky.

Mulder helped lead Vincennes University to a 33–2 record, earned JUCO All-America honors and was rated the 13th-best junior-college prospect in the country by 247Sports.com's composite ranking.

Murray's stock began to soar following a breakout performance at the Nike Hoop Summit against the USA Basketball Team.

He scored 30 points against the United States prior to a 29-point, 10-assist, eight-rebound effort in the BioSteel All-Canadian Basketball Game.

[10][11] Sources: On April 9 the University of Kentucky held a press conference for all players that intended to declare for the 2015 NBA draft.

Seven players declared themselves eligible for the draft: Booker, Cauley-Stein, the Harrison twins (Aaron and Andrew), Johnson, Lyles, and Towns.

[17][18] On June 24 Murray announced his decision to Kentucky televised on Canada's TSN, donning a Canadian flag.

[23] USA Today announced its initial coaches poll on October 15 with Kentucky ranked as No.

[30] Bam Adebayo, originally from Pinetown, North Carolina, was a consensus top 15 player in his class.

[5] De'Aaron Fox, originally from Katy, Texas, was the second highest rated point guard that Calipari had signed at Kentucky.

[5] Sacha Killeya-Jones, originally from Chapel Hill, North Carolina, was the second commitment in the Kentucky class.

[5] Malik Monk, originally from Bentonville, Arkansas, was the second highest rated shooting guard that Calipari signed at Kentucky.

[35] He chose Kentucky over Arkansas where his brother, Marcus Monk, played college basketball and football.

[5] Sources: Roster Last update: December 18, 2015 The season officially began on November 13 with a 78–65 victory over Albany in the first game of the HoopHall Invitational at Rupp Arena.

[43][44] Kentucky entered its game against Boston U. on November 24 ranked number one in the country for the first time this season.

[45][46] The night after Thanksgiving, on November 27, Kentucky traveled to Miami to play South Florida in the Hoops Hall Invitational.

[47][48] On November 30 Kentucky returned home to defeat Illinois State 75–63 behind 16 points from Murray.

[49][50] On December 3 Kentucky traveled to Los Angeles to play UCLA for their first meeting ever in Pauley Pavilion.

[53][54] On December 12 Kentucky hosted Arizona State and defeated the Sun Devils 72–58 behind 14 points and 7 rebounds from Lee.

[55][56] On December 19 Kentucky traveled to Brooklyn to play in the annual CBS Sports Classic against Ohio State.

[57][58] On December 26 Kentucky returned home to play in the annual Battle for the Bluegrass against Louisville.

For the second consecutive year Ulis was named MVP of the game after a 21 points, 8 assist performance to lead Kentucky to a 75–73 victory.

[59][60] Kentucky opened conference play against Ole Miss on January 2 at Rupp Arena.

[65][66] On January 12 Kentucky returned to Rupp Arena defeat Mississippi State 80–74 behind 22 points from Murray.

[71][72] Two days later Kentucky returned to Rupp Arena to defeat Vanderbilt 76–57 behind 21 points from Ulis.

[97][98] On January 13 Murray and Ulis were two of three SEC players (with Ben Simmons) named to the 25-man John R. Wooden Award midseason watchlist.

[101][102] On March 5 Ulis was one of fourteen players named as a Wooden Award finalist by the Los Angeles Athletic Club.

[105] On December 7 Briscoe was named SEC Freshman of the Week after scoring 19 points in games against Illinois State and UCLA.

[106] On December 14 Murray was named SEC Freshman of the Week after 16.5 points, a guard-best 5.0 rebounds and 4.5 assists in wins over Eastern Kentucky and Arizona State.