The 2015–16 Liga Femenina de Baloncesto was the 53rd edition of the Spanish premier women's basketball championship.

Perfumerías Avenida won its fourth title after defeating Spar Citylift Girona 2–1 in the Championship Finals.

At the end of the 2014–15 season, Campus Promete and CB Al-Qazeres Extremadura were relegated to Liga Femenina 2.

However, only the first one managed to gather the requirements for registration, therefore Campus Promete was offered the vacant spot.

Its spot was filled by Iraurgi Saski Baloia,[1] team that had not been admitted in Liga Femenina 2 before.