The 2015–16 Louisville Cardinals men's basketball team represented the University of Louisville during the 2015–16 NCAA Division I men's basketball season.

The Cardinals competed in their second season in the Atlantic Coast Conference and were coached by Rick Pitino, in his 15th season at U of L. The team played its home games on Denny Crum Court at the KFC Yum!

The University of Louisville self-imposed a postseason ban for the 2015–16 season amid an ongoing NCAA investigation over an escort sex scandal involving recruits between 2010 and 2014.

Louisville defeated UC Irvine, Northern Iowa, and NC State to advance to the Elite Eight where they lost to Michigan State.

Sources: Sources: Roster * Following the announcement of their self-imposed postseason ban, they were no longer eligible for ranking in the coaches poll.