The 2015–16 Macedonian First League was the 24th season of the Macedonian First League, with 8 teams participating in it.
Regular season started on October 10, 2015, and finished on April 23, 2016, followed by the playoffs, with the six best placed teams joining it.
In quarterfinals, if one of the teams won the two regular season games against its rival, a first win is awarded in the best-of-five series.