[1] Hibernians were the defending champions, having won their 11th title the previous season.
[3] Pietà Hotspurs and Żebbuġ Rangers were relegated after they finished eleventh and twelfth, respectively, the previous season.
Pembroke Athleta, the 2014–15 First Division champion, made their debut in the Premier League.
Runner-up St. Andrews returned to the highest level for the first time since the 1993–94 season.
A play-off match took place between St. Andrews, the tenth-placed team from the Premier League and Senglea Athletic, the third-placed team from the First Division for a place in the 2016–17 Maltese Premier League.