It was originally scheduled to be played at California Memorial Stadium in Berkeley,[3] but it was moved to reduce the amount of travelling the team would have to do.

[4] Four days later, Manchester United faced European champions Barcelona at Levi's Stadium in Santa Clara, California, before completing the campaign at Chicago's Soldier Field with a game against Paris Saint-Germain.

[7] Manchester United began their campaign with a 1–0 win at home to Tottenham Hotspur on 8 August, with an own goal from Kyle Walker proving the difference between the two teams.

[11] In the final fixture before the first international break, United conceded their first goals of the season as they lost 2–1 to Swansea City at the Liberty Stadium.

After going ahead early in the second half through Juan Mata, they conceded twice in five minutes just after the hour mark, first to a header from André Ayew, who then provided the assist for Bafétimbi Gomis.

Christian Benteke then pulled one back for Liverpool with a bicycle kick before deadline day signing Anthony Martial scored a debut goal to seal a 3–1 win.

Arsenal drew first blood through an Alexis Sánchez goal in the sixth minute before Mesut Özil added to the score barely 74 seconds later.

Watford equalised late on through a Troy Deeney penalty, but then he put it into his own goal in stoppage time to give United back–to–back victories.

United returned to winning ways in their next match, defeating arch-rivals Liverpool 1–0, courtesy of a late Wayne Rooney strike.

[17] However United struggled initially to build on this victory, losing their next match at home to Southampton, with Charlie Austin scoring a late winner.

[20] Jesse Lingard opened the scoring on the hour mark, before a defensive lapse allowed Diego Costa to rescue a point for Chelsea in the closing stages of the match.

Anthony Martial cancelled out an early Wahbi Khazri opener, before a De Gea own goal provided Sunderland with the three points.

Danny Welbeck and Mesut Özil both scored for Arsenal, yet Rashford's brace and a deflected Ander Herrera effort secured the win for United.

United won their opening fixture in March, defeating a stubborn Watford side 1–0, with Juan Mata securing the three points with an 83rd minute free-kick.

[24] However United failed to capitalise on this opportunity, losing 3–2 at West Ham, a club that also had an outside chance of claiming a top-four finish.

[26] This bizarre set of circumstances deprived United of a chance to apply pressure on City, who ultimately drew to Swansea to secure a top-four finish.

United's match against Bournemouth was re-arranged for 17 May, two days after intended kick-off, and they closed the campaign in style, winning 3–1 with goals from Wayne Rooney, Marcus Rashford and Ashley Young.

Manager Louis van Gaal was under pressure for Manchester United's poor form prior to the match, and the victory was compared to one in the same competition in 1990, in which a goal by Mark Robins reportedly saved the career of Alex Ferguson.

[29] Twenty days later in the next round, United travelled to Pride Park to play Derby County, situated in the play-off places in the Championship.

The visitors took the lead via a free-kick from Dimitri Payet, and only seven minutes remained when the hosts equalised with Anthony Martial's close-range finish.

West Ham halved the deficit late on after James Tomkins' header passed into David de Gea's net, and they threatened an equaliser but could not achieve it.

After the break, a penalty was given when Timothy Fosu-Mensah fouled Ross Barkley, but De Gea saved the spot-kick after Romelu Lukaku took it.

Everton brought on Gerard Deulofeu whose cross was put into United's net via a Chris Smalling own goal to level the scores.

Chris Smalling became the fourth player in FA Cup final history to be sent off, for a second bookable offence just before the end of the first period of extra time.

With 10 minutes to go, Jesse Lingard scored the winner for United with a right-foot volley, clinching the club's record-equalling 12th FA Cup.

[35] As one of eight English clubs who qualified for European competition in the 2014–15 season, United received a bye to the third round of the League Cup.

United were drawn in a two-legged tie against Belgian Pro League runners-up Club Brugge,[40] which they won 7–1 on aggregate, ensuring their place in the group stage after a one-season absence.

Manchester United were drawn into Group B with Dutch champions PSV, the runners-up from Russia and Germany, CSKA Moscow and VfL Wolfsburg.

[43] United suffered a shock defeat to PSV in the first game as the hosts came from behind to win 2–1, after Depay scored the opener following his brace against Club Brugge in the play-offs.

In the 24th minute, United's in-form left-back Luke Shaw suffered a broken leg in a challenge with Moreno, keeping him out for six months.