The 2015–16 Melbourne City FC W-League season was the club's inaugural season in the W-League, following the announcement of the team's formation on 13 May 2015.

[1] The team is based at the City Football Academy, training on the Academy Pitches at La Trobe University and playing home games at both AAMI Park and CB Smith Reserve.

[2] The club had a remarkably successful season, winning all 12 of its regular season games and achieving success in the 2016 W-League grand final, completing a perfect season, to claim both a maiden regular season premiership and an end of season championship.

[3] Correct as of 30 October 2015 Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.