The 2015–16 Moldovan National Division (Romanian: Divizia Națională) is the 25th season of top-tier football in Moldova.
Speranța Nisporeni, which became third in the 2014–15 "A" Division, returns to the highest level for the first time since the 1997–98 season.
The champions of the 2014–15 "A" Division, FC Sheriff-2, are not allowed to play in the same league as the first Sheriff team, and thus were not promoted.
The "home" team (for administrative purposes) was determined by an additional draw held on 22 May 2016.
During the first two rounds, each team plays each other once home and away for a total of 18 matches.