The 2015–16 Northern Iowa Panthers men's basketball team represented the University of Northern Iowa during the 2015–16 NCAA Division I men's basketball season.

The Panthers, led by tenth year head coach Ben Jacobson, played their home games at the McLeod Center and were members of the Missouri Valley Conference (The Valley).

The Panthers defeated Southern Illinois, Wichita State, and Evansville to win the Missouri Valley tournament and earn the conference's automatic bid to the NCAA tournament.

11 seed, they defeated Texas in the first round to advance to the second round, where they lost to the Texas A&M Aggies in double overtime after suffering the greatest collapse in NCAA Tournament history, blowing a 12 point lead with 35 seconds left in regulation.

They defeated Bradley, Loyola–Chicago, and Illinois State to win the Missouri Valley tournament and received the conference's automatic bid to the NCAA tournament.