The 2015–16 Oklahoma State Cowboys basketball team represented Oklahoma State University in the 2015–16 NCAA Division I men's basketball season.

This was head coach Travis Ford's eighth and final season at Oklahoma State.

The Cowboys were members of the Big 12 Conference and played their home games at Gallagher-Iba Arena.

On March 18, Oklahoma State and Travis Ford mutually parted ways.

They received an at-large bid to the NCAA tournament where they lost in second round to Oregon.