The 2015–16 Penn State Nittany Lions basketball team represented Pennsylvania State University in the 2015–16 NCAA Division I men's basketball season.

They played its home games in University Park, Pennsylvania at the Bryce Jordan Center, with two games at Rec Hall, and were members of the Big Ten Conference.

They lost to Ohio State in the second round of the Big Ten tournament.

The Nittany Lions finished the 2014–15 season with an overall record of 18–16, with a record of 4–14 in the Big Ten regular season to finish in 13th place.

They advanced to the quarterfinals of the Big Ten tournament where they lost to Purdue.