The reigning champions entering the season were Saracens, who had claimed their second title after defeating Bath in the 2015 final.

Saracens won their third title after defeating Exeter Chiefs in the final at Twickenham having also topped the regular season table.

The competition began slightly later than normal, due to the 2015 Rugby World Cup taking place in England and in a slight change to usual, the London Double Header at Twickenham, the twelfth instance since its inception in 2004, was played in round 5 instead of round 1.

The series was won by Welsh region Newport Gwent Dragons who beat Premiership side Wasps in the final.

The London Irish v Saracens match – played in Round 16 on 12 March 2016 – took place at the Red Bull Arena in Harrison, New Jersey.

This match – originally scheduled to be held during Round 9, on 8 January 2016 – was postponed due to a European Rugby Champions Cup fixture rearrangement that occurred as a result of the Paris terrorist attacks in November 2015.