The regular season started on September 11, 2015, and ended on April 30, 2016.
Inter Movistar are the defending champions by defeating ElPozo Murcia 3 games to 1 in the 2014–15 Championship Final series, winning its tenth title overall and second in a row.
Uruguay Tenerife and Prone Lugo finished in the last two places in the league and so were relegated at the end of the 2014-2015 regular season.
UMA Antequera were crowned 2014-2015 champions of Segunda División de Futsal and were promoted automatically.
Elche lost the promotion playoffs 2 games to 0 to CD Brihuega FS, but because of money issues Elche became the other team to be promoted to the Primera División for the 2015-2016 season.