The 2015–16 Regional Four Day Competition was the 50th edition of the Regional Four Day Competition, the domestic first-class cricket competition for the countries of the West Indies Cricket Board (WICB).

Six teams contested the tournament – Barbados, Guyana, Jamaica, the Leeward Islands, Trinidad and Tobago, and the Windward Islands.

Guyana were undefeated, winning eight of their ten matches and drawing the other two, and consequently won their eighth title (and second in a row).

Jamaica's Nikita Miller was the leading wicket-taker, while Guyana's captain Leon Johnson led the competition in runs.

The top five run-scorers are included in this table, listed by runs scored and then by batting average.