The 2015–16 season is the fifth season of the SEHA (South East Handball Association) League and second under the sponsorship of the Russian oil and gas company Gazprom.

Ten teams from seven countries (Bosnia and Herzegovina, Croatia, Macedonia, Hungary, Slovakia, Serbia and Belarus) will participate in this year's competition.

The SEHA League consists of two phases – the first has 18 rounds in which all teams play one home and one away game against each other.

The campaign began on 1 September 2015 with the match between the defending champions Veszprém and last year's runner-up Meshkov Brest.

The regular season will end on 13 March 2016, while the Final Four tournament will be held in Varaždin from 1 to 3 April 2016.