The 2015–16 Saint Louis Billikens men's basketball team represented Saint Louis University in the 2015–16 NCAA Division I men's basketball season.

The Billikens were led by fourth year head coach Jim Crews.

After a terrible 2014-2015 campaign, three of Saint Louis's top players (Grandy Glaze, Austin McBroom, and Tanner Lanconca) decided to leave the program and John Manning graduated from the University.

With these four leaving the program Saint Louis lost 303 games of experience and 95 starts from the combined group.

This marked a second consecutive year with massive turnover in the players in the program.