The 2015–16 San Francisco Dons women's basketball team represented the University of San Francisco in the 2015–16 college basketball season.

It was head coach Jennifer Azzi's sixth season at San Francisco.

The Dons, members of the West Coast Conference, played their home games at War Memorial Gymnasium.

They won the WCC women's tournament and earn automatic trip to NCAA women's tournament for the first time since 1997.

On September 15, 2016, Azzi resigned as head coach of the Dons to pursue new career opportunities.