The 2015–16 South Florida Bulls men's basketball team represented the University of South Florida during the 2015–16 NCAA Division I men's basketball season.

The Bulls were coached by Orlando Antigua, who was in his second season.

The Bulls played their home games at the USF Sun Dome on the university's Tampa, Florida campus.

They beat East Carolina in the first round of the AAC tournament before losing to Temple in the quarterfinals.

They lost in the first round of the AAC tournament to UConn.