The 2015–16 Spartan South Midlands Football League season was the 19th in the history of Spartan South Midlands Football League a football competition in England.
The Premier Division featured 19 clubs which competed in the division last season, along with three clubs promoted from Division One: Five clubs have applied for promotion to Step 4: AFC Dunstable, Berkhamsted, Hertford Town, Hoddesdon Town and London Colney.
Division One featured 20 clubs in the division for this season, of which there are five new clubs.
In addition, Bush Hill Rangers changed their name to Woodford Town.
Division Two featured twelve clubs which competed in the division last season, along with six new clubs: