The Huskies, led by thirty first year head coach Geno Auriemma, won the NCAA tournament and went undefeated.

[3] UConn commits Napheesa Collier and Crystal Dangerfield both played at the 2015 FIBA Under-19 World Championship for Women, held in Chekhov, Russia from 8 to 26 July 2015.

[5][6] Three UConn players participated in basketball at the 2015 Pan American Games held in Toronto, Ontario, Canada July 10 to 26, 2015.

Lizanne Murphy and Nirra Fields hit three-pointers to help extend the lead to 68–39 at the end of three quarters.

[8] The gold-medal game matched up the host team Canada against USA, in a sold-out arena dominated by fans in red and white and waving the Canadian flag.

[13] Nurse played for Canada at the 2015 FIBA Americas Women's Championship, a qualifying event used to determine invitations to the 2016 Olympics.

Canada was assigned to Group A and played Puerto Rico, Chile, the Dominican Republic and Cuba in the preliminary rounds.

Canada led by only six points at halftime but gradually expanded the lead to end up with an 83–66 win, and a spot in the gold-medal game.

Playing without Taya Reimer and Briana Turner, Notre Dame opted for a guard-oriented, perimeter offense.

The Raiders were unable to keep up with the Huskies, but did manage to accomplish something that recent opponents had exploited, namely, hitting three-pointers.

[30] UConn faced Florida State in the Hall of Fame Women's Showcase played at the Mohegan Sun Arena.

However, the Huskies had a balanced offense, led by Tuck with 18 points, and Stewart with 16, Jefferson with 15, and Nurse with 14; the quartet was more than enough to counter Florida State.

Even with some of the Huskies being sidelined, UConn played solid defense, holding LSU scoreless for a six-minute stretch at one time, and held them to just under 26% field goal shooting.

The Terrapins were ranked sixth in the polls, but the Huskies started out strong, opening up a seven-point lead at the end of the first quarter.

Connecticut continued the run in the opening minutes of the second half, scoring the first four points of the period, but Maryland responded, and retook the lead.

Maryland would make one more basket, but five three throws by Connecticut extended the final margin to double digits, and a win 81–71.

Jefferson had noticed a tendency to shoot with her elbow out, corrected the motion, and hit seven of her eight field goal attempts, leading to a team high 21 points.

The team hit almost 55% of their field goal attempts, and tied a season high with 13 three-pointers, leading to 104 points, while holding Temple to 49.

UConn recorded assists on 25 of their 32 baskets, hit 58% of their field goal attempts, as well as all ten free throws.

Stewart, who was only 16 points away from second place (held by Tina Charles) on the Huskies all-time scoring list.

Although the new lineup had an early 15–7 lead, the score was tied at 15 apiece late in the first quarter, when Auriemma brought in the seniors.

The four seniors, Breanna Stewart, Mariah Jefferson, Morgan Tuck, and Brianna Pulido, walked out onto the floor with family members and were given a framed memento including their jersey.

This year ceremonies included Stewart and Jefferson, both of whom had attained the first-team All-America status, as well as Chris Dailey, the associate head coach.

[56] UConn found itself in unfamiliar territory, as they went into the halftime break trailing by a single point to South Florida.

The large lead allowed the coach to rest the starters and give the bench plenty of time on the court.

Jefferson was given the assignment of guarding Courtney Williams, the best player for South Florida, and held her to a single basket in the first half.

The last time the Huskies lost in the first round of the NCAA tournament was 1993, before any of the current UConn players were born.

Despite setting a record for the most wins in program history with 28, the Mississippi State Bulldogs were never in the game, and ended up losing 98–38.

The 60 point margin of victory established a new NCAA record in the regional rounds or beyond set by Connecticut in the previous year in a 51-point win over Texas.

[68] The Huskies' exhibition game with Vanguard featured several experimental rules, many of which have been advocated by head coach Auriemma:[69] [70] Breanna Stewart, Moriah Jefferson and Morgan Tuck were the first, second and third pick of the 2016 WNBA draft.