The 2015–16 UEFA Youth League Domestic Champions Path were played from 29 September to 6 December 2015.
A total of 32 teams competed in the Domestic Champions Path to decide 8 of the 24 places in the knockout phase of the 2015–16 UEFA Youth League.
The draw was held on 1 September 2015, 13:45 CEST, at the UEFA headquarters in Nyon, Switzerland.
[5][6] There were no seedings, but the 32 teams were split into four groups defined by sporting and geographical criteria prior to the draw.
The team that scored more goals on aggregate over the two legs advanced to the next round.
If away goals were also equal, the match was decided by a penalty shoot-out (no extra time was played).
[1] The eight second round winners advanced to the play-offs, where they were joined by the eight group runners-up from the UEFA Champions League Path.